Yearly Archives: 2014

How lizards regenerate their tails: researchers discover genetic ‘recipe’

A team of researchers from Arizona State University have discovered the genetic “recipe” for lizard tail regeneration.

“Using next-generation technologies to sequence all the genes expressed during regeneration, we have unlocked the mystery of what genes are needed to regrow the lizard tail,” said lead author Kenro Kusumi. “By following the genetic recipe for regeneration that is found in lizards, and then harnessing those same genes in human cells, it may be possible to regrow new cartilage, muscle or even spinal cord in the future.”

The findings are published in the journal PLOS ONE.

Making Old Bones New Again

“A new study from biomedical engineers at Rensselaer Polytechnic Institute demonstrates how the compound N-phenacylthiazolium bromide, or PTB, dissolves the sugary impurities within bone tissue that cause our femurs, fibulas, and other bones to become more fragile. Using PTB to reduce bone fragility and boost bone flexibility could lead to new strategies for preventing bone fractures in elderly individuals, as well as accelerated bone healing in patients with diabetes or osteoporosis.”

See more here.

Revolutionary new blood test ‘could detect ALL types of cancer’

From the DailyMail:

“A revolutionary blood test that could detect any type of cancer has been developed by British scientists.
It is hoped the breakthrough will enable doctors to rule out cancer in patients presenting with certain symptoms – saving time and preventing costly and unnecessary invasive procedures and biopsies.
Early results have shown the simple test can diagnose cancer and pre-cancerous conditions from the blood of patients with melanoma, colon cancer and lung cancer with a high degree of accuracy.”

Google’s New Moonshot Project: the Human Body

Google has announced a new ‘baseline’ study of the human body. Here’s the story from the WSJ.

“Google has embarked on what may be its most ambitious and difficult science project ever: a quest inside the human body.

Called Baseline Study, the project will collect anonymous genetic and molecular information from 175 people—and later thousands more—to create what the company hopes will be the fullest picture of what a healthy human being should be.”

Silicon Valley Moves the Needle on Curing Aging

Here’s a piece I wrote for Slate.

“Silicon Valley, known for entrepreneurs, gadget lovers, and paradigm breakers, has recently turned its attention towards longevity, powering an important cultural change on the topic. The interests of these movers and shakers run the gamut, from using technology to improve our clunky healthcare system to literally solving the problem of aging.”

Read more here.

Silicon Valley’s 40 OVER 40 list!

Thanks, TechCrunch! While most publications put together a “40 under 40″ list, TechCrunch decided to take on the myth that only young people innovate. Here’s their 40 OVER 40 list of SV digerati.

Frank Barbieri, who put together the list with Sarah Buhr, wrote a thoughtful post explaining why he felt it was time for such a list to be created.

“The myth of older founders is pernicious: too comfortable, they don’t think big enough, not hungry enough, etc. Elon Musk doesn’t think big enough? Hadi Partovi is resting on his laurels with the founding of code.org? Where does the correlation of age to the myth of The Valley hero/heroine come from? One of the very founders of Silicon Valley itself Robert Noyce founded Intel when he was 41.”

In a related side note, Twitter is currently being sued for age discrimination (lawsuit filed last week). Here’s the story from SF Weekly.

Science Fiction Becomes Science-Fact: Two Strategies for Repairing Humans

Here’s my first article in a series for Slate magazine on longevity. Thanks to Prudential for sponsoring my obsession with health extension!

“Not long ago, it would have sounded like science fiction to discuss growing human organs in the lab or re-writing DNA. Yet today both are realities that will change the world and allow for longer and healthier lives.

Already, lab-grown bladders, windpipes and blood vessels have been successfully created and implanted into humans. Most recently, tissue engineering pioneer Dr. Anthony Atala and his team at the Wake Forest Institute for Regenerative Medicine announced another breakthrough: lab-made vaginas—one of the most complex organs made to date. In four girls with MRKH syndrome, a medical condition in which the vagina and uterus are underdeveloped or absent, Dr. Atala’s team was able to create new organs that functioned normally, dramatically increasing each patient’s quality of life.

[...]

Read more here.

US regulators fast-track novel leukemia therapy

The FDA is looking to speed up the availability of a new technique that put 89 percent of cancer patients into remission. Here’s the story.

“The personalized immunotherapy known as CTL019 was developed by the University of Pennsylvania and was designated a “breakthrough therapy” by the US Food and Drug Administration.

That means the experimental therapy will benefit from a speedier than average review process and will get extra attention from the FDA toward development for market.”

KQED Launches ‘PriceCheck’ to Make Health Costs Transparent

It’s rather amazing that no one has done this yet. Kudos to KQED for launching this new database. To contribute your data, click here. From the KQED blog:

“It’s well known to health policy types, but less so to consumers, that health care prices are utterly lacking in transparency and wildly variable.

If you’ve ever looked at a bill for a health care procedure — and been astounded by the numbers you see — or thought that you would like to find the best price on an elective procedure – and been astounded that there’s no easy way to compare prices — KQED is launching a new project for you.”

New method for delivering stem cells helps heal bone

From Singularity Hub:

“One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.”

[...]

“University of Rochester biomedical engineer Danielle Benoit encapsulated bone progenitor cells in a hydrogel wrapper and placed it on the bone she aimed to heal. Benoit hoped the wrapper would result in fewer stem cells being washed away and more sticking around to do the work of healing the bone.”

‘Bionic pancreas’ for diabetes patients passes test

From AP:

“Scientists have made big progress on a “bionic pancreas” to free some people with diabetes from the daily ordeal of managing their disease. A wearable, experimental device passed a real-world test, constantly monitoring blood sugar and automatically giving insulin or a sugar-boosting drug as needed, doctors said Sunday.”

Baby’s genome sequenced before birth

From MIT Tech Review:

“An infant delivered last week in California appears to be the first healthy person ever born in the U.S. with his entire genetic makeup deciphered in advance.

His father, Razib Khan, is a graduate student and professional blogger on genetics who says he worked out a rough draft of his son’s genome early this year in a do-it-yourself fashion after managing to obtain a tissue sample from the placenta.”

An At-Home Medical Device That Cuts Out Trips to the Doctor

This seems like a super-cool device! I hope the FDA approves it quickly — I want one.

From Wired:

“The iPhone has enabled all sorts of crazy interactions, but a new device called Cue could be the first iOS accessory that uses boogers as a primary user input. The tabletop analyzer brings the power of a medical laboratory into the home and allows people to test their levels of testosterone, inflammation, vitamin D, and fertility with small amounts of blood, saliva, or nasal swabs.”

Ageism in Hollywood

Norman Lear, producer of ground-breaking shows such as All in the Family, Maude, and The Jeffersons says he’s facing agism among those who fund TV shows. The 91 year old, who loves to take on controversial issues, says that no one is interested in hearing about his idea of a comedy in a retirement village.

“They don’t want to touch the demographic,” he said. Apparently, he said, there’s only room for one old person (that would be another comedy veteran, Betty White, who actually is a few months older than Lear) on network television today. The name of the show Lear has been pitching is Guess Who’s Dead?, a title that got a huge laugh from the audience.”