“Scientists have found a new family of molecules that kill cancer cells and protect healthy cells, which could be used to treat a number of different cancers. Research shows that as well as targeting and killing cancer cells, the molecules generate a protective effect against toxic chemicals in healthy cells.”
“A one-day event with leading influencers and visionaries to reimagine the American dream in an intimate setting at The Battery in San Francisco. NOVUS is a tour de force that unites global shapers from around the world to tackle the today’s grand challenges via actionable change. “
“Over the past few years, researchers have reversed muscle atrophy, memory loss, heart degradation and some of the effects of cognitive decline by pumping the blood of young mice into old mice. The results from these animal experiments were so intriguing that last year a team at Stanford University began the ultimate rejuvenation trial: giving blood plasma from under 30s to people with Alzheimer’s. Results are expected next year.
Now, Benjamin Alman, a professor of surgery at the Hospital for Sick Children in Toronto, Canada, and his colleagues have tested young blood’s ability to heal bones.”
“It can take weeks to identify drugs targeting cancer-causing mutations. Watson can do it in minutes and has in its database the findings of scientific papers and clinical trials on particular cancers and potential therapies.”
“So far, the medical implant has been tested in three children between the ages of 3 months and 16 months. Before getting the implant, the young patients had spent much of their lives in intensive care, where they needed to be on ventilators full-time to help them breathe. But after surgeons inserted the small white device around their narrow airways, all three recovered rapidly, according to a study published this week in the journal Science Translational Medicine.”
Scientists controlled a mouse’s behavior using a method called “DREADDs (designer receptors exclusively activated by designer drugs).” Not a great acronym (given the potential abuse for such a method), but it does reflect a shift away from linking mental “illnesses to “chemical imbalances” in the brain, instead tracing them to miswiring and misfiring in neuronal circuits.” Here’s the story.
“What do you do when a patient needs a blood transfusion but you don’t have their blood type in the blood bank? It’s a problem that scientists have been trying to solve for years but haven’t been able to find an economic solution – until now.
University of British Columbia chemists and scientists in the Centre for Blood Research have created an enzyme that could potentially solve this problem. The enzyme works by snipping off the sugars, also known as antigens, found in Type A and Type B blood, making it more like Type O. Type O blood is known as the universal donor and can be given to patients of all blood types.”
Read more at: http://phys.org/news/2015-04-donated-blood-universal.html#jCp
Here’s the latest news piece to cite 100 Plus. The author interviewed some naysayers on the topic of healthspan, but ultimately I think it’s clear that if Silicon Valley can figure out how to increase human health, that is a good thing for everyone.
Researchers at Duke University have engineered a polio virus to infect cancer cells. This weakens the cancer and alerts the body’s immune system to the fact that there is something growing in the body that shouldn’t be there. It’s brilliant work and 60 Minutes has done a great job of capturing the story. Watch it here.
“The company has hired Richard Scheller, who led drug discovery at biotech icon Genentech for 14 years before announcing he would retire in December, and who has won some of science’s top awards, including the Lasker Prize, often referred to as “America’s Nobel,” and the Kavli Prize.”
“A new class of drugs has been identified that slow the ageing process in mice, alleviating symptoms of frailty and extending a healthy lifespan.
If their effect on humans is as marked as it is on animal models, their benefit could be enormous.
The research was carried out by a team from Mayo Clinic, The Scripps Institute and other institutions and published in the journal Aging Cell yesterday.
“We view this study as a big, first step toward developing treatments that can be given safely to patients to extend healthspan or to treat age-related diseases and disorders,” said co-lead author and TSRI Professor Paul Robbins, PhD.”
Two significant news hits on Alzheimer’s recently. One team in Australia is experimenting (on mice) with ultrasound to clear up plaque buildup and the other team (in the US) is using an already approved drug commonly used to treat epilepsy to calm hyperactivity in the brain.
It was a pleasure to meet Dr. Craig Venter at Stanford this week. As you can imagine, he had strong views and a huge amount of energy. I’m super-interested in all of his work, but was surprised to find out about his efforts to fight the spread of influenza using genomics. He convinced me that it is possible to create an annual flu vaccine that actually targets the flu of that year. That would be useful.
Lots of people I know will be interested in this. Here’s the story from the researchers at Sanford-Burnham.
“We have developed a method using human pluripotent stem cells to create new cells capable of initiating human hair growth. The method is a marked improvement over current methods that rely on transplanting existing hair follicles from one part of the head to another,” said Alexey Terskikh, Ph.D., associate professor in the Development, Aging, and Regeneration Program. “Our stem cell method provides an unlimited source of cells from the patient for transplantation and isn’t limited by the availability of existing hair follicles.”
Yesterday, I visited with a bunch of scientists from UCSF’s Lim Lab. They had a cool simulation game to show how CAR-T therapy works. Essentially, you want to make your “T” cell recognize the cancer cell so it will kill it. I did it on the first try — super-fun!