More great work from Wake Forest:
New research in mice and rats, conducted at Wake Forest Baptist Medical Center’s Institute for Regenerative Medicine, suggests that “in body” regeneration of muscle tissue might be possible by harnessing the body’s natural healing powers.
Reporting online ahead of print in the journal Acta Biomaterialia, the research team demonstrated the ability to recruit stem cells that can form muscle tissue to a small piece of biomaterial, or scaffold that had been implanted in the animals’ leg muscle. The secret to success was using proteins involved in cell communication and muscle formation to mobilize the cells.
“Working to leverage the body’s own regenerative properties, we designed a muscle-specific scaffolding system that can actively participate in functional tissue regeneration,” said Sang Jin Lee, Ph.D., assistant professor of regenerative medicine and senior author. “This is a proof-of-concept study that we hope can one day be applied to human patients.”
A team of researchers from Arizona State University have discovered the genetic “recipe” for lizard tail regeneration.
“Using next-generation technologies to sequence all the genes expressed during regeneration, we have unlocked the mystery of what genes are needed to regrow the lizard tail,” said lead author Kenro Kusumi. “By following the genetic recipe for regeneration that is found in lizards, and then harnessing those same genes in human cells, it may be possible to regrow new cartilage, muscle or even spinal cord in the future.”
The findings are published in the journal PLOS ONE.
“A class of bacteria commonly found in the guts of people—and rodents—appears to keep mice safe from food allergies, a study suggests. The same bacteria are among those reduced by antibiotic use in early childhood.” From Sciencemag.org.
Chatting with genomics pioneer George Church and cryobiologist Greg Fahy at the Rejuvenation Biotechnology conference. Thanks to Aubrey de Grey and the SENS team for a great event!
“A new study from biomedical engineers at Rensselaer Polytechnic Institute demonstrates how the compound N-phenacylthiazolium bromide, or PTB, dissolves the sugary impurities within bone tissue that cause our femurs, fibulas, and other bones to become more fragile. Using PTB to reduce bone fragility and boost bone flexibility could lead to new strategies for preventing bone fractures in elderly individuals, as well as accelerated bone healing in patients with diabetes or osteoporosis.”
See more here.
Researchers at John Hopkins University in Baltimore found that variations in a single gene can be used to predict if someone is likely to take their own life. Here’s the story. Interestingly, the same researchers also found a genetic marker for postpartum depression.
Google has announced a new ‘baseline’ study of the human body. Here’s the story from the WSJ.
“Google has embarked on what may be its most ambitious and difficult science project ever: a quest inside the human body.
Called Baseline Study, the project will collect anonymous genetic and molecular information from 175 people—and later thousands more—to create what the company hopes will be the fullest picture of what a healthy human being should be.”
Here’s a well written article from Nature about how scientists should be focusing on aging in order to
1) treat a number of diseases and
2) extend healthspan for the many people who are in the ‘older’ demographic
Here’s a piece I wrote for Slate.
“Silicon Valley, known for entrepreneurs, gadget lovers, and paradigm breakers, has recently turned its attention towards longevity, powering an important cultural change on the topic. The interests of these movers and shakers run the gamut, from using technology to improve our clunky healthcare system to literally solving the problem of aging.”
Read more here.
Thanks, TechCrunch! While most publications put together a “40 under 40″ list, TechCrunch decided to take on the myth that only young people innovate. Here’s their 40 OVER 40 list of SV digerati.
Frank Barbieri, who put together the list with Sarah Buhr, wrote a thoughtful post explaining why he felt it was time for such a list to be created.
“The myth of older founders is pernicious: too comfortable, they don’t think big enough, not hungry enough, etc. Elon Musk doesn’t think big enough? Hadi Partovi is resting on his laurels with the founding of code.org? Where does the correlation of age to the myth of The Valley hero/heroine come from? One of the very founders of Silicon Valley itself Robert Noyce founded Intel when he was 41.”
In a related side note, Twitter is currently being sued for age discrimination (lawsuit filed last week). Here’s the story from SF Weekly.
Here’s my first article in a series for Slate magazine on longevity. Thanks to Prudential for sponsoring my obsession with health extension!
“Not long ago, it would have sounded like science fiction to discuss growing human organs in the lab or re-writing DNA. Yet today both are realities that will change the world and allow for longer and healthier lives.
Already, lab-grown bladders, windpipes and blood vessels have been successfully created and implanted into humans. Most recently, tissue engineering pioneer Dr. Anthony Atala and his team at the Wake Forest Institute for Regenerative Medicine announced another breakthrough: lab-made vaginas—one of the most complex organs made to date. In four girls with MRKH syndrome, a medical condition in which the vagina and uterus are underdeveloped or absent, Dr. Atala’s team was able to create new organs that functioned normally, dramatically increasing each patient’s quality of life.
Read more here.
The FDA is looking to speed up the availability of a new technique that put 89 percent of cancer patients into remission. Here’s the story.
“The personalized immunotherapy known as CTL019 was developed by the University of Pennsylvania and was designated a “breakthrough therapy” by the US Food and Drug Administration.
That means the experimental therapy will benefit from a speedier than average review process and will get extra attention from the FDA toward development for market.”
It’s rather amazing that no one has done this yet. Kudos to KQED for launching this new database. To contribute your data, click here. From the KQED blog:
“It’s well known to health policy types, but less so to consumers, that health care prices are utterly lacking in transparency and wildly variable.
If you’ve ever looked at a bill for a health care procedure — and been astounded by the numbers you see — or thought that you would like to find the best price on an elective procedure – and been astounded that there’s no easy way to compare prices — KQED is launching a new project for you.”
From Singularity Hub:
“One trouble with stem cells is that they don’t stay put. When doctors put cardiovascular progenitor cells in the heart to heal damage from a heart attack, the cells are whisked away in the bloodstream in a matter of hours.”
“University of Rochester biomedical engineer Danielle Benoit encapsulated bone progenitor cells in a hydrogel wrapper and placed it on the bone she aimed to heal. Benoit hoped the wrapper would result in fewer stem cells being washed away and more sticking around to do the work of healing the bone.”
That’s what scientists at the Harvard Stem Cell Institute are working on. They’ve already had success in mice, “permanently reducing cholesterol levels in mice with a single injection, potentially reducing heart attack risk by up to 90 percent.” Great work — hope it will translate for human patients as well!
This seems like a super-cool device! I hope the FDA approves it quickly — I want one.
“The iPhone has enabled all sorts of crazy interactions, but a new device called Cue could be the first iOS accessory that uses boogers as a primary user input. The tabletop analyzer brings the power of a medical laboratory into the home and allows people to test their levels of testosterone, inflammation, vitamin D, and fertility with small amounts of blood, saliva, or nasal swabs.”